Hits a three-wheeler in the outskirts of Skegness (7)
I believe the answer is:
strikes
'hits' is the definition.
('strike' can be a synonym of 'hit')
'a three-wheeler in the outskirts of skegness' is the wordplay.
'a three-wheeler' becomes 'trike' (I've seen this before).
'in the' is an insertion indicator.
'outskirts of' means to remove the middle letters.
'skegness' with its centre removed is 'ss'.
'trike' going within 'ss' is 'STRIKES'.
(Other definitions for strikes that I've seen before include "(Takes) industrial action" , "Hits" , "Impresses" .)