Hogshead is as much as one can hold - otherwise, it could be dangerous (7)
I believe the answer is:
harmful
'be dangerous' is the definition.
(similar in meaning)
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for harmful that I've seen before include "Causing injury or damage, say poison or malice" , "Injurious" , "Deleterious" , "Dangerous, damaging" , "Noxious" .)