Hold Inca, not loosely (7)
I believe the answer is:
contain
'hold' is the definition.
(synonyms)
'inca not loosely' is the wordplay.
'loosely' is an anagram indicator (a looser version of the letters).
'inca'+'not'='incanot'
'incanot' with letters rearranged gives 'CONTAIN'.
(Other definitions for contain that I've seen before include "keep within bounds" , "I cannot (anag) - hold back" , "Enclose" , "Accommodate" , "Hold within, suppress (7)" .)