Hold up from coach in derailment (6)
I believe the answer is:
hinder
'hold up' is the definition.
(I've seen this before)
'from coach in derailment' is the wordplay.
'from' says the answer is hidden in the clue.
'HINDER' can be found hidden inside 'coach in derailment'.
(Other definitions for hinder that I've seen before include "Obstruct, impede" , "Prevent progress" , "Impede, keep back" , "Delay progress, obstruct" , "Bow user" .)