Holiday destination in October emptied among others (6)
I believe the answer is:
resort
'holiday destination' is the definition.
(I've seen this before)
'october emptied among others' is the wordplay.
'emptied' suggests removing the centre.
'among' is an insertion indicator.
'others' becomes 'rest' (I've seen this before).
'october' with its middle taken out is 'or'.
'or' going within 'rest' is 'RESORT'.
'in' is the link.
(Other definitions for resort that I've seen before include "Put fresh order" , "Where people engage in recreation" , "Make an anagram of" , "Source of help - holiday location" , "repair" .)