Holy man's upset by eviscerated Hindu (5)
I believe the answer is:
sadhu
'holy man's' is the definition.
(I've seen this before)
'upset by eviscerated hindu' is the wordplay.
'upset' becomes 'sad' (I've seen this before).
'by' is a charade indicator (letters next to each other).
'eviscerated' says to hollow out the word (remove centre letters) (the word is disembowelled of its inside letters).
'hindu' with its centre taken out is 'hu'.
'sad'+'hu'='SADHU'
(Other definitions for sadhu that I've seen before include "Indian holy man or sage" , "Indian wandering holy man" , "Hindu wandering holy man" , "one choosing austerity" , "Ascetic" .)