Home can be the first place to run! (4)
I believe the answer is:
base
'home' is the definition.
(thesaurus)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for base that I've seen before include "Not worth much" , "Found - station - contemptible" , "Interest charged by the Bank of England to commercial banks" , "Infamous" , "centre from which soldiers operate" .)