Home Counties remedy, safe (6)
I believe the answer is:
secure
'safe' is the definition.
('secure' can be a synonym of 'safe')
'home counties remedy' is the wordplay.
'home counties' becomes 'se'.
'remedy' becomes 'cure' ('cure' can be a synonym of 'remedy').
'se'+'cure'='SECURE'
(Other definitions for secure that I've seen before include "in the bag" , "Safe and unthreatened" , "Firm; safe" , "Safe and well-protected" , "land" .)