Home-grown new musical coming up (6)
I believe the answer is:
native
'home-grown' is the definition.
(similar in meaning)
'new musical coming up' is the wordplay.
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'musical' becomes 'evita' (Andrew Lloyd Webber musical).
'coming up' is a reversal indicator (in a down clue, letters go up).
'evita' in reverse letter order is 'ative'.
'n'+'ative'='NATIVE'
(Other definitions for native that I've seen before include "One born in a certain place" , "Of person, belonging by birth to place" , "Indigenous, aboriginal" , "Indigenous person" , "One who belongs to place by birth" .)