Home I abandon, the ultimate in cruelty and wickedness (8)
I believe the answer is:
iniquity
'wickedness' is the definition.
(I've seen this before)
'home i abandon the ultimate in cruelty' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'abandon' becomes 'quit' (quitting is a kind of abandoning**).
'the ultimate in' indicates one should take the final letters.
The last letter of 'cruelty' is 'y'.
'in'+'i'+'quit'+'y'='INIQUITY'
'and' acts as a link.
(Other definitions for iniquity that I've seen before include "Going wrong" , "Evil, wickedness" , "immorality" , "Sin" , "Gross injustice; crime" .)