Home in centre? Middle of nowhere! (6)
I believe the answer is:
hearth
'home' is the definition.
(hearth is a kind of home)
'centre? middle of nowhere' is the wordplay.
'centre?' becomes 'heart' ('heart' can be a synonym of 'centre').
'middle of' says to take the centre.
The centre of 'nowhere' is 'h'.
'heart'+'h'='HEARTH'
'in' is the link.
(Other definitions for hearth that I've seen before include "Fireplace surround" , "a warm, welcoming place" , "Floor of a fireplace in the home" , "Area around fireplace" , "Part of fireplace symbolising home" .)