Home of the indigenous Plains Indians originally (4)
I believe the answer is:
tipi
'home' is the definition.
(tipi is a kind of home)
'the indigenous plains indians originally' is the wordplay.
'originally' says to take the initial letters.
The first letters of 'the indigenous plains indians' is 'TIPI'.
'of' acts as a link.
(Other definitions for tipi that I've seen before include "home to Delaware, perhaps" , "Tent" .)