Hooligan’s fate blocked by university (4)
I believe the answer is:
lout
'hooligan's' is the definition.
(both can mean an aggressive person)
'fate blocked by university' is the wordplay.
'fate' becomes 'lot' (synonyms).
'blocked by' means one lot of letters goes inside another (block can mean to plug a gap in something).
'university' becomes 'U' (abbreviation for university).
'lot' going around 'u' is 'LOUT'.
(Other definitions for lout that I've seen before include "Boor, oaf" , "A coarse ill-mannered fellow" , "Uncouth man" , "Antisocial person" , "Uncouth chap" .)