Hope abandoned with trouble over tragic role (7)
I believe the answer is:
ophelia
'tragic role' is the definition.
(character in Hamlet)
'hope abandoned with trouble over' is the wordplay.
'abandoned' indicates anagramming the letters.
'with' means one lot of letters go next to another.
'trouble' becomes 'ail' ('ail' can be a synonym of 'trouble'**).
'over' says the letters should be written in reverse.
'ail' reversed gives 'lia'.
'hope' with letters rearranged gives 'ophe'.
'ophe'+'lia'='OPHELIA'
(Other definitions for ophelia that I've seen before include "she's a part to play" , "girl in play" , "Tragic heroine" , "Daughter of Polonius (Hamlet)" , "She drowned dramatically" .)