Horrible old male shot out of hand (9)
I believe the answer is:
loathsome
'horrible' is the definition.
(thesaurus)
'old male shot out of hand' is the wordplay.
'old' becomes 'o' (abbreviation).
'out of hand' indicates an anagram.
'o'+'male'+'shot'='omaleshot'
'omaleshot' is an anagram of 'LOATHSOME'.
(Other definitions for loathsome that I've seen before include "15 [ABHORRENT]" , "gross" , "Horrid" , "Detestable" , "Hateful" .)