Horrid and nasty, terribly up itself (8)
I believe the answer is:
spiteful
'horrid and nasty' is the definition.
I can't tell whether this definition defines the answer.
'terribly up itself' is the wordplay.
'terribly' is an anagram indicator.
'up'+'itself'='upitself'
'upitself' anagrammed gives 'SPITEFUL'.
Can you help me to learn more?
(Other definitions for spiteful that I've seen before include "Malevolent, wanting to hurt" , "Vengeful, malicious" , "With desire to hurt" , "Showing malice" , "nasty!" .)