Hostile African country with guns regularly seen (6)
I believe the answer is:
malign
'hostile' is the definition.
(thesaurus)
'african country with guns regularly seen' is the wordplay.
'african country' becomes 'mali' (I've seen this before).
'with' means one lot of letters go next to another.
'regularly seen' indicates alternate letters.
The alternate letters of 'guns' are 'gn'.
'mali'+'gn'='MALIGN'
(Other definitions for malign that I've seen before include "Laming, showing malice" , "Wicked, evil" , "Evil, malevolent" , "Traduce" , "Calumniate" .)