Hostile once more on way (7)
I believe the answer is:
against
'hostile' is the definition.
(thesaurus)
'once more on way' is the wordplay.
'once more' becomes 'again' (synonyms).
'on' is a charade indicator (letters next to each other).
'way' becomes 'st' (abbreviation for street).
'again'+'st'='AGAINST'
(Other definitions for against that I've seen before include "Not supporting" , "In competition with" , "Disapproving of" , "antagonistic" , "Facing" .)