Hotel is in luck -- maids regularly ignored fool (7)
I believe the answer is:
fathead
'fool' is the definition.
(I know that fathead is a type of fool)
'hotel is in luck maids regularly ignored' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'is in' is an insertion indicator.
'luck' becomes 'fate' (synonyms).
'regularly ignored' indicates alternate letters (letters removed at regular intervals).
The alternate letters of 'maids' are 'ad'.
'h' going inside 'fate' is 'fathe'.
'fathe'+'ad'='FATHEAD'
(Other definitions for fathead that I've seen before include "silly ass!" , "Fool" , "Charlie" , "Stupid person" , "Slang idiot with enlarged cranium?" .)