Hotels lie in opposite directions (4)
I believe the answer is:
inns
'hotels' is the definition.
(inn is a kind of hotel)
'in opposite directions' is the wordplay.
'opposite directions' becomes 'ns' (opposite compass points).
'in'+'ns'='INNS'
'lie' acts as a link.
I am not very happy about this link. It may belong to another bit of the clue.
(Other definitions for inns that I've seen before include "Bars" , "Drink here and learn about the King's law" , "Old-time hostelries" , "Country taverns" , "King's ..., for the legal eagles" .)