House infiltrated by a shrew (6)
I believe the answer is:
virago
'shrew' is the definition.
(I know that Virago is a type of shrew)
'house infiltrated by a' is the wordplay.
'house' becomes 'virgo' (astrological 'house' associated with Virgo).
'infiltrated by' is an insertion indicator.
'virgo' enclosing 'a' is 'VIRAGO'.
(Other definitions for virago that I've seen before include "Scolding or domineering woman" , "Manlike woman?" , "Bad-tempered woman" , "Loudly fierce or abusive woman" , "domineering female" .)