House with tailless mice? That's funny! (5)
I believe the answer is:
comic
'funny' is the definition.
(comic can mean funny or humorous)
'house with tailless mice?' is the wordplay.
'house with' becomes 'co' (I can't explain this - if you can you should believe this answer much more).
'tailless' means to remove the last letter (the tail of the word is removed).
'mice' with its final letter taken away is 'mic'.
'co'+'mic'='COMIC'
'that's' is the link.
Can you help me to learn more?
(Other definitions for comic that I've seen before include "Funny entertainer, often stand-up" , "Funny, ridiculous" , "Funny man, maybe stand-up" , "Stand-up possibly" , "Raising a laugh" .)