How can she be Lois? (6)

I believe the answer is:
isobel
'how can' is the definition.
The definition suggests a singular noun which matches the answer.
'she be lois?' is the wordplay.
'be lois' anagrams to 'ISOBEL'.
But, I am unsure how this is indicated.
Can you help me to learn more?
(Another definition for isobel that I've seen is " Lobs, i.e. into a girl's name".)
I've seen this clue in the Evening Standard.
Want a hint initially instead of a full solution?
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