How flawless execution proceeds, despite all one's efforts? (4,3,4,4,2,3,5)

I believe the answer is:

with the best will in the world

'despite all one's efforts?' is the definition.
(phrase meaning 'despite good intentions')

I don't understand how the remainder of the clue works.

(Other definitions for with the best will in the world that I've seen before include "however good her intentions" , "...most easily thus" .)

I've seen this clue in The Guardian.

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