How sanctimonious setter might be compared to you! (6-4-4)
I believe the answer is:
holier-than-thou
'how sanctimonious' is the definition.
'holier-than-thou' can be an answer for 'sanctimonious' (synonyms). I am not certain of the 'how' bit.
'setter might be compared to you' is the wordplay.
'setter might be' becomes 'holier' (I can't explain this - if you can you should believe this answer much more).
'compared to' becomes 'than' (I've seen this before).
'you' becomes 'thou' (historical second person pronoun).
'holier'+'than'+'thou'='HOLIER-THAN-THOU'
Can you help me to learn more?
(Other definitions for holier-than-thou that I've seen before include "Self-righteous" , "Sanctimonious" .)