However, they'll return to Elizabeth I with potato (5)
I believe the answer is:
tuber
'potato' is the definition.
(potato is an example of a tuber)
'however they'll return to elizabeth i' is the wordplay.
I cannot really see how this works, but
'elizabeth' could be 'er' and 'er' is found within the answer.
The remaining letters 'tub' is a valid word which might be clued in a way I don't see.
This may be the basis of the clue (or it may be nonsense).
'with' is the link.
Can you help me to learn more?
(Other definitions for tuber that I've seen before include "Fleshy underground root" , "Eg, dahlia root" , "Fleshy underground stem (eg of the potato)" , "traveller down in London?" , "Thickened underground stem" .)