Humor with a twist (5)
I believe the answer is:
irony
'humor with a twist' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for irony that I've seen before include "Conveying meaning by expressing the opposite" , "Scornful wit" , "sarcastic wit" , "Subtle humour" , "Socrates used it" .)