I fret less with files organised into spreads individually (4-10)
I believe the answer is:
self-fertilises
'spreads individually' is the definition.
I know nothing about this answer so I can't judge whether it can be defined by this definition.
'i fret less with files organised' is the wordplay.
'with' means one lot of letters go next to another.
'organised' indicates an anagram.
'i'+'fret'+'less'+'files'='ifretlessfiles'
'ifretlessfiles' with letters rearranged gives 'SELF-FERTILISES'.
'into' is the link.
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