I leave after a male friend (5)
I believe the answer is:
amigo
'friend' is the definition.
('friend' in Spanish)
'i leave after a male' is the wordplay.
'leave' becomes 'go' (to go is to depart or leave).
'after' is a charade indicator (letters next to each other).
'male' becomes 'm' (common abbreviation).
'i'+'go'='igo'
'a'+'m'='am'
'igo' put after 'am' is 'AMIGO'.
(Other definitions for amigo that I've seen before include "Friend from Spain?" , "Foreign ally" , "Mate in Madrid?" , "friend in Uruguay" , "in a foreign land, my friend?" .)