I regret not a silly question (11)
I believe the answer is:
interrogate
'question' is the definition.
('interrogate' can be a synonym of 'question')
'i regret not a silly' is the wordplay.
'silly' indicates an anagram.
'regret'+'not'+'a'='regretnota'
'regretnota' anagrammed gives 'nterrogate'.
'i'+'nterrogate'='INTERROGATE'
(Other definitions for interrogate that I've seen before include "Formally question" , "Question closely" , "Cross-examine" , "Ask questions of (someone)" .)