Ignore changes, in part (6)
I believe the answer is:
region
'part' is the definition.
(region is a kind of part)
'ignore changes' is the wordplay.
'changes' indicates an anagram.
'ignore' anagrammed gives 'REGION'.
'in' is the link.
(Other definitions for region that I've seen before include "Tract or area" , "Part of a country" , "Area, territory" , "Area, location" , "Area,territory" .)