Ignore heart on cuckoo's wings — impossible! (2,3,2)
'impossible' is the definition.
('no can do' can mean something is impossible)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for no can do that I've seen before include "Can't manage it, see doc anon" , "That's out of the question!" , "Unable to help" , "Impossible, I'm afraid!" , "off-putting response" .)
'wings impossible' is the definition.
I don't know anything about this answer so I can't judge whether this works.
'ignore heart on cuckoo's' is the wordplay.
'heart' says to take the centre.
'on cuckoo' becomes 'cando' (I can't explain this - if you can you should believe this answer much more).
The middle of 'ignore' is 'no'.
'no'+'cando'='NOCANDO'
Can you help me to learn more?