Ignore rearrangement of a district (6)
I believe the answer is:
region
'a district' is the definition.
(I've seen this in another clue)
'ignore rearrangement' is the wordplay.
'rearrangement' indicates an anagram.
'ignore' with letters rearranged gives 'REGION'.
'of' acts as a link.
(Other definitions for region that I've seen before include "Area, domain" , "Kind of territory to ignore" , "Part of a country" , "Tract or area" , "Area - district" .)