Ignore scruffy area (6)
I believe the answer is:
region
'area' is the definition.
(I know that area can be written as region)
'ignore scruffy' is the wordplay.
'scruffy' is an anagram indicator (I've seen this in other clues).
'ignore' is an anagram of 'REGION'.
(Other definitions for region that I've seen before include "Kind of territory to ignore" , "Area, zone" , "Ignore (anag) -- expanse of land" , "Area, neighbourhood" , "Area, domain" .)