Ignoring every other part, turn exact handle (5)
I believe the answer is:
treat
'handle' is the definition.
(synonyms)
'ignoring every other part turn exact' is the wordplay.
'ignoring every other part' means one should take alternating letters.
'turn'+'exact'='turnexact'
The alternating letters of 'turnexact' are 'TREAT'.
(Other definitions for treat that I've seen before include "Handle - delightful surprise" , "Deal with sickness" , "pleasant surprise" , "Tetra (anag.)" , "Negotiate to reach an agreement" .)