Illnesses with man taken short, going to wrong loo! (8)
I believe the answer is:
maladies
'illnesses' is the definition.
('malady' can be a synonym of 'illness')
'man taken short going to wrong loo' is the wordplay.
'taken short' means to remove the last letter.
'going to' is a charade indicator (letters next to each other).
'wrong loo' becomes 'ladies' (I can't justify this - if you can you should give a lot more credence to this answer).
'man' with its final letter taken off is 'ma'.
'ma'+'ladies'='MALADIES'
'with' is the link.
Can you help me to learn more?
(Other definitions for maladies that I've seen before include "Complaints" , "illnesses" , "Diseases, ailments" .)