I'm out of aspirin ordered for the injury (6)
I believe the answer is:
sprain
'the injury' is the definition.
(sprain is a kind of injury)
'i'm out of aspirin ordered' is the wordplay.
'i'm' becomes 'i' (I've seen this in other clues).
'out of' indicates named letters should be taken away ('out of' can mean no longer having).
'ordered' indicates anagramming the letters.
'aspirin' with 'i' removed is 'asprin'.
'asprin' anagrammed gives 'SPRAIN'.
'for' acts as a link.
(Other definitions for sprain that I've seen before include "Injury to the ankle, say" , "Wrench, the ankle say" , "sign of strain" , "Injure a joint by twisting its ligaments" , "Wrench (a ligament) (P, not T)" .)