Improvised setter's cue on origin of universe (9)
I believe the answer is:
impromptu
'improvised' is the definition.
(I've seen this before)
'setter's cue on origin of universe' is the wordplay.
'setter's' becomes 'I'm' (referring to the crossword setter).
'cue on' becomes 'prompt' (prompt is a kind of cue. I am not sure about the 'on' bit.).
'origin of' suggests taking the first letters.
The first letter of 'universe' is 'u'.
'im'+'prompt'+'u'='IMPROMPTU'
Can you help me to learn more?
(Other definitions for impromptu that I've seen before include "Piano piece" , "Spontaneous" , "unrehearsed piece" , "Unplanned; composition" , "Unprepared" .)