Impudence — annoy (4)
![Ross](/clue/static/ross-mug.min.png)
I believe the answer is:
gall
I believe this is a double definition.
'impudence' is the first definition.
(synonyms)
'annoy' is the second definition.
(gall can mean to annoy)
(Other definitions for gall that I've seen before include "Audacity" , "A sore spot or a bodily bladder" , "Spleen or brass neck" , "Brass nedk or bile" , "Bitterness of feeling or bodily bladder" .)