In a hotel shown in large book (2,4)
I believe the answer is:
at home
'in' is the definition.
(I've seen this before)
'a hotel shown in large book' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'shown in' means one lot of letters goes inside another.
'large book' becomes 'tome' (I've seen this before).
'h' put into 'tome' is 'thome'.
'a'+'thome'='AT-HOME'
(Other definitions for at home that I've seen before include "ready to receive visitors" , "Comfortable - in one's own country" , "In (for a party?)" , "Where one lives" , "Oh mate! (anag)" .)