In Acapulco mickey-taking is funny (5)
I believe the answer is:
comic
'is funny' is the definition.
(comic can mean funny or humorous)
'in acapulco mickey-taking' is the wordplay.
'in' indicates the answer is hidden within the clue.
'COMIC' is hidden in the letters of 'acapulco mickey taking'.
(Other definitions for comic that I've seen before include "Wag" , "Professional funny person" , "Children's publication" , "Funny; comedian" , "Victor once, say" .)