In bed, a lot twisted and swollen (7)
I believe the answer is:
bloated
'swollen' is the definition.
('bloated' can be a synonym of 'swollen')
'in bed a lot twisted' is the wordplay.
'in' indicates putting letters inside.
'twisted' indicates anagramming the letters.
'a'+'lot'='alot'
'alot' with letters rearranged gives 'loat'.
'bed' enclosing 'loat' is 'BLOATED'.
'and' is the link.
(Other definitions for bloated that I've seen before include "Swollen with fluid or gas" , "Swollen with fluid/gas" , "More than fed up" , "Swollen with gas, liquid or pride" , "Distended" .)