In beer, has it nothing but bitter associations? (4)
I believe the answer is:
aloe
'it nothing but bitter associations?' is the definition.
The definition suggests a singular noun which matches the answer.
'in beer has' is the wordplay.
'in' indicates putting letters inside.
'beer' becomes 'ale' (type of beer).
'has' becomes 'o' (I am not sure about this - if you are sure you should believe this answer much more).
'ale' placed around 'o' is 'ALOE'.
Can you help me to learn more?
(Other definitions for aloe that I've seen before include "Bitter drug from a leaf juice" , "Fleshy-leaved plant" , "shrub" , "Succulent plant (4) 5532" , ". . . . vera, soothing plant" .)