In charge of you and me. editor may be worn out (8)
I believe the answer is:
overused
'be worn out' is the definition.
(worn out can mean overused or overdone)
'in charge of you and me editor' is the wordplay.
'in charge of' becomes 'over' (eg a manager works over other people).
'you and me' becomes 'us'.
'editor' becomes 'ed' (abbreviation).
'over'+'us'+'ed'='OVERUSED'
'may' acts as a link.
(Other definitions for overused that I've seen before include "Hackneyed" , "Employed excessively for tasks, probably worn" , "Revues do tend to be excessively utilised" .)