In disagreement (2,4)
'in disagreement' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for at odds that I've seen before include "Opposed, in conflict with" , "Not in agreement" , "Quarrelling" , "In disagreement or conflict - like bookies?" , "On bad terms" .)
(Other definitions for out of step that I've seen before include "misreading the Zeitgeist" , "not with the rest" , "Not in conformity" , "failing to conform" , "at odds with others" .)