In fight, large Italian twisting blade (8)
I believe the answer is:
stiletto
'blade' is the definition.
(I have seen 'Thin blade ' mean 'stiletto' so perhaps 'blade' could also mean 'stiletto')
'in fight large italian twisting' is the wordplay.
'in' is an insertion indicator.
'fight' becomes 'setto' (set-to can mean a fight or argument).
'large' becomes 'L' (eg in clothes sizes).
'italian' becomes 'it' (abbreviation for Italian).
'twisting' is a reversal indicator (letters twist back).
'l'+'it'='lit'
'lit' back-to-front is 'til'.
'setto' enclosing 'til' is 'STILETTO'.
(Other definitions for stiletto that I've seen before include "Possible cause of stabbing pains" , "Bedspread" , "Dagger with slender blade" , "Pointed arm" , "Dagger with narrow blade, or a high heel" .)