In general, to make progress (3,2)
I believe the answer is:
get on
'make progress' is the definition.
(synonyms)
'in general to' is the wordplay.
'in' is an insertion indicator.
'general' becomes 'gen'.
'gen' enclosing 'to' is 'GET ON'.
(Other definitions for get on that I've seen before include "Board vehicle or make progress" , "Hit it off" , "What boarders do" , "Advance; prosper" , "Make progress, do well in life" .)