In ‘House of Sin', play the baddies (8)
I believe the answer is:
villains
'baddies' is the definition.
(I've seen this before)
'in house of sin play' is the wordplay.
'in house of' becomes 'villa' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'play' is an anagram indicator.
'sin' is an anagram of 'ins'.
'villa'+'ins'='VILLAINS'
'the' acts as a link.
Can you help me to learn more?
(Other definitions for villains that I've seen before include "Wicked people" , "Baddies" , "Scoundrels, miscreants" .)