In love, you and me after a second run out (7)
I believe the answer is:
amorous
'in love' is the definition.
(I've seen this before)
'you and me after a second run out' is the wordplay.
'you and me' becomes 'us'.
'after' is a charade indicator (letters next to each other).
'second' becomes 'mo' (both are short periods of time).
'run out' becomes 'ro' (cricket abbreviation).
'a'+'mo'+'ro'='amoro'
'us' after 'amoro' is 'AMOROUS'.
(Other definitions for amorous that I've seen before include "Feeling desire" , "In loving mood" , "Lustful" , "Inclined towards displaying love" , "Relating to love" .)