In painful condition, love to leave the house (2,3)
I believe the answer is:
go out
'leave the house' is the definition.
('go out' can be a synonym of 'leave the house')
'in painful condition love' is the wordplay.
'in' means one lot of letters goes inside another.
'painful condition' becomes 'gout'.
'love' becomes 'o' (In tennis, 'love' means 'zero').
'gout' going around 'o' is 'GO OUT'.
'to' is the link.
(Other definitions for go out that I've seen before include "Become extinguished" , "become unfashionable" , "Leave or exit the house (2.3)" , "leave home" .)